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Category 3, with the most rigorous facilities and testing, can assign BUDs up to 180 days

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UNC School of Medicine: Kodoth V et al

Activation of GPR41 increases the secretion of intestinal peptide YY (PYY) and decreases the secretion of glucose-dependent insulin-releasing polypeptide (GIP) and growth hormone-releasing peptide, thereby reducing glucose uptake (Hu et al., 2018)