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Description
The first six amino acids of native GLP-1 are absent, and two key substitutions are introduced: at position 8, alanine is replaced by 2-aminoisobutyric acid (Aib) to prevent degradation by dipeptidyl peptidase-4 (DPP-4), and at position 34, lysine is replaced by arginine to improve stability

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By week 4, most participants escalated to .5 mg

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