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Diarrhea: Diarrhea is another common gastrointestinal side effect of GLP-1 medications, characterized by loose or watery stools

GLP-1R blockade with the antagonist exendin(939) impaired glucose tolerance in WT mice but had no effect in Pdx1-hGLP1R:Glp1r/ mice

they are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or MEN 2

For those who are eligible, it also offers a reduced risk for side effects and a shorter period of recovery.

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