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Treatment may continue with doctors increasing the dosage by 0.5 mg each week

doi:10 Holst JJ

After 2 weeks of treatment, mice treated with GLP-1MK-801, as well as those subjected to calorie restriction or GLP-1 monotherapy, demonstrated enhanced glucose tolerance compared with mice that were treated with the vehicle or MK-801 monotherapy (Extended Data Fig

However, women should stop the medication at least 2 months before actively trying to conceive due to potential fetal exposure risks

Assessing the requirement of CD36 for GLP-2-mediated increases in intestinal-TG secretion are complicated by the increased fatty acid absorption (as shown by appearance of radiolabel in plasma), TRL-TG and TRL-apoB48 secreted by Cd36 / mice compared to wild-type controls (Hsieh et al., 2009)