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Sitagliptin administered to the high-fatfed human islet amyloid polypeptide (HIP) rat model of type 2 diabetes amplified the increased pancreatic duct cell replication present in that model (27)

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did not directly point out the treatment potential of GLP-1R agonists for DPN, these results may support the peripheral neuroprotective effect of GLP-1R agonists considering the close association of DPN with adverse limb events (60)

This sparked further advancements, including Novo Nordisks development of more potent analogs like liraglutide and semaglutide, with the latter achieving over $12 billion in sales by 2022