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Retrieved from Popoviciu, M., Pduraru, L., Yahya, G., et al

If successful, future work investigating the combination of an SGLT2i with a dual continuous glucose and ketone sensor may allow individuals with type 1 diabetes to access SGLT2i therapy

Standard semaglutide titration: Weeks 1-4: 0.25 mg weekly Weeks 5-8: 0.5 mg weekly Weeks 9-12: 1.0 mg weekly Week 13+: 1.7 mg or 2.4 mg weekly (target dose) Hashimoto's-adjusted approach: Weeks 1-6: 0.25 mg weekly (extended to allow thyroid monitoring at week 6) Weeks 7-12: 0.5 mg weekly (TSH check before increasing) Weeks 13-16: 1.0 mg weekly Week 17+: Assess whether higher doses are needed The extended timeline allows for thyroid function checks at each step, ensuring levothyroxine doses are adjusted proactively rather than reactively

Preserving lean mass blunts that drop, making it easier to maintain the lower weight

In severe cases, this can lead to malnutrition, dehydration, organ failure, and serious hospitalization