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In fact, particularly the circumventricular organs with their GLP1 receptors present some conundrum

Cheong SH, Furuhashi K, Ito K, Nagaoka M, Yonezawa T, Miura Y, Yagasaki K (2014) Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice

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Significant improvement over single agonist but still lacks the energy expenditure component

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