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However, previous large-scale trials comparing intensive versus standard glycemic control, such as ACCORD and ADVANCE, demonstrated that while intensive glucose lowering modestly reduced the incidence of nonfatal MI, it did not significantly reduce CV mortality among patients with T2D (70, 72, 73)

The mechanism is straightforward: less fat around the neck and upper airway means less airway collapse during sleep

Symptoms to watch for include upper abdominal pain, fever, jaundice (yellowing of the skin or eyes), and pale, clay-colored stools

Retatrutides glucagon component appears particularly adept at addressing hepatic steatosis (fatty liver)