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In SURMOUNT-5, once weekly tirzepatide at the maximum tolerated dose (MTD 10 mg or 15 mg) compared with semaglutide (MTD 1.7 mg or 2.4 mg) resulted in significantly greater body weight reduction in adults living with obesity without T2D

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Secondary endpoints included the rate of patients with a weight loss of10%, monthly headache days (MHD), the rate of patients with a30% and50% reduction in MHD, visual outcome parameters, and adverse events (AEs)

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The balance between germline s...