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In Phase 1 single-ascending-dose studies, the mean half-life ranged from 24.6 to 35.3 hours across the 0.3 to 6 mg dose range

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Almost half of the participants in the semaglutide arm (48.2%) still had clinically meaningful weight loss of 5% or more from baseline at week 120, although this proportion represented a substantial fall from that originally achieved at the end of 68 weeks of treatment (86.4%)

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