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Semaglutide was also associated with a 4.5- to 6.4-kg weight loss

As a member of the mammalian sirtuins family, Sirt3 is a mitochondrion-localized histone deacetylase, which is highly expressed in mitochondria-rich tissues and plays a key regulatory role in the development of glioblastoma [87]

Moreover, we retrieved other relevant records 56,57,58 : two large ( N = 133,318 and N = 342,608, respectively) cohort studies in people with diabetes across 613 years noted a beneficial association between GLP-1RA prescriptions compared with non-prescription and lower diagnoses of dementia 57,58 , while a small ( N = 154 patients with T2DM) and shorter (~12 months) cross-sectional investigation of GLP-1RAs in addition to metformin, compared with metformin alone, observed better MoCA scores in the former group 56

Although the EDE-Q provides a comprehensive profile of eating-disorder symptoms, it is relatively lengthy and more detailed than is practical for rapid routine screening, making it better suited for diagnostic evaluation or monitoring rather than brief assessment in settings where GLP-1 RAs are prescribed

However, concerns have persisted regarding their potential association with pancreatitis