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Engineered bacteria manipulate cysteine metabolism to boost ferroptosis-based pancreatic ductal adenocarcinoma therapy

Biomarkers such as GPX4 expression levels (210) accumulation of the lipid peroxidation product 4-HNE, and the transport activity of ABCC2 have emerged as valuable indicators for patient stratification, prognosis prediction, and therapeutic monitoring (211, 212)

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