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Patients with elevated VAT should prioritize dual or triple agonists (tirzepatide, retatrutide) for their enhanced effects on fat distribution and energy expenditure

The safety profile was favorable with predominantly mild to moderate gastrointestinal adverse events and low discontinuation rates of 0.5-1.5%

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Metformin treatment improves erectile function in an angiotensin II model of erectile dysfunction

Peak drug concentration climbs steeply with each escalation before settling which is why GI side effects cluster during escalation windows and typically improve as each new dose level reaches steady state