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The list of species and NCBI accession numbers, as well as the corresponding peptide sequences, are provided in Supplementary Tables 15 and 16

Trp 33* is a key residue of the GLP-1R epitope and its hydrophobic binding site is defined by Tyr 51 , Leu 94 , Phe 96 and Tyr 108 (CDR2 VH, CDR3 VL and CDR3 VH) (Fig

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NCL is a chemoselective process that enables the efficient and high-yielding ligation of two unprotected peptide segmentsin aqueous solution and under mild reaction conditionsgenerating a native peptide bond