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Studies on GLP-1 receptor agonists suggest that a third or more of the weight lost may come from lean muscle tissue

Novel pharmaceuticals in appetite regulation: exploring emerging gut peptides and their pharmacological prospects

Studies demonstrate that semaglutide primarily reduces fat mass while preserving muscle tissue, with approximately 65% of weight loss coming from fat reduction.[6] Recent clinical trials show that combining semaglutide with resistance training and adequate protein intake can preserve 50-80% of lean mass that might otherwise be lost during weight reduction

Opioid use disorder investigations

There are only two GLP-1 agonists that are TGA approved for weight loss, semaglutide ( Wegovy brand) and liraglutide ( Saxenda )