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[DOI] [PubMed] [Google Scholar] 122.Quitadamo P., Zenzeri L., Mozzillo E., Giorgio V., Rocco A., Franzese A., Nardone G., Staiano A

After bariatric surgery, particularly sleeve gastrectomy and gastric bypass, endogenous GLP-1 levels rise significantly, improving insulin sensitivity, glucose regulation, and appetite control

Rotating injection sites systematically and avoiding injection immediately before bed (which may cause pressure on the site) can minimise discomfort

But these arent barriers that cant be overcome
