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Efficacy and Safety of Once-Weekly Semaglutide 20 mg Versus 10 mg in Patients With Type 2 Diabetes (SUSTAIN FORTE): A Double-Blind, Randomised, Phase 3B Trial

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The prediction: By Q4 2027, fewer than 12% of commercial plans will cover Wegovy without step therapy requirements

Therefore, although the two domain model suggests that the activating N-terminal region of the peptide agonists must be delivered to the core domain via binding of the C-terminus to the NTD, this 11-mer agonist suggests that it is nevertheless possible to obtain high potency from the secondary interaction
