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While retatrutide is being developed primarily as an obesity and diabetes treatment, the triple-agonist mechanism has implications beyond weight loss

CONCLUSION The potential of these new therapies to effectively treat obesity and T2DM and radically reduce their complications pose a major challenge to the health authorities who will need to decide how these new possibilities should be implemented to the benefit of the people at risk

doi: 10.1016/S0196-9781(99)00024-8 136 AsarianLGearyN

Potentiation of the cAMP accumulation produced by GLP-1(9-36) in combination with various fixed concentrations of positive allosteric modulator using mutant GLP-1R transiently transfected into HEK293 cells

This mechanism makes it especially attractive for patients with obesity complicated by metabolic disorders such as type 2 diabetes and metabolic dysfunctionassociated fatty liver disease (MAFLD)