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The older GLP-1 medications activate one or two receptors in the brain and throughout the body, whereas retatrutide works by activating three receptors

The results showed that GLP-1 agonists have a favorable safety profile, with most side effects being mild and temporary

Many of these peptides have been found to be critical physiological regulators of appetite, energy expenditure, and glucose and lipid metabolism, making them good mechanistic candidates for improved metabolism after surgery