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Through paracrine signaling from cells, GLP1 enhances insulin secretion, which in turn suppresses glucagon release from cells

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Combinations of GLP-1 with other entero-pancreatic hormones with complementary actions and/or synergistic potential (such as glucose-dependent insulinotropic polypeptide (GIP), glucagon, and amylin) are under investigation to enhance the weight loss and cardiometabolic benefits of GLP-1 RA [21]

The thyroid produces hormones that regulate metabolic rate throughout the body
