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They took blockbuster drugs for weight loss and diabetes

2020;45(Suppl 1):4360

Then, protein kinase A (PKA) phosphorylates and activates cAMP response element-binding protein (CREB), a nuclear transcription factor that is constitutively expressed and involved in regulating the expression of genes related to neuronal survival and function

With inspiration from Rolf Mentlein in Kiel, Holst and Deacon showed that the GLP-1 molecule was cleaved by the enzyme dipeptidyl-peptidase-4(DPP-4) in vivo and that inhibitors of this enzyme could completely protect the molecule (43)

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