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Looking ahead, the influence of US policy and Most Favoured Nation (international reference) pricing will remain a central trend that shaped obesity care in 2025 and will continue to do so into 2026 and beyond

6.2 pounds with a placebo

For the latter, it is not only known that PAR2 signaling induces IR in adipocytes (125), but PAR2 might also be a substantial contributor to inflammatory and metabolic dysfunction (126)