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The science: Muscle tissue is metabolically activeit generates heat even at rest Studies show that without adequate protein intake and resistance training, up to 25% of weight lost can be lean muscle mass Muscle has a higher metabolic rate than fat tissue (~13 kcal/kg/day for muscle vs ~4.5 kcal/kg/day for fat) Why you feel cold: Less muscle = less heat production

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Feeding rats with fructo-oligosaccharide as a source of SCFAs has also shown to upregulate FFAR2 (270)

The total weekly dose remains 8mg, but the peak plasma concentration is lower, which reduces GI symptoms for many researchers

In clinical trials, individuals on retatrutide shed up to 24% of their body weight over 48 weeks, with some participants dropping almost 29% at 68 weeks, particularly at the highest dose tested, which is 12 mg a week