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The data on this is limited for retatrutide since it is newer, but the general pattern with GLP-1 agonists suggests that maintaining weight loss after stopping requires lifestyle modifications regardless of which compound you used

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While the risk is low, monitor blood glucose closely if utilizing this formulation in conjunction with insulin or sulfonylureas

Jonsson also brought up bimagrumab, which is in a phase 2 trial, and could potentially help prevent muscle loss associated with incretins