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Three weeks later, mice were terminally anaesthetised with 100 mg/kg pentobarbital and transcardially perfused with PBS containing 4% PFA, brains were collected, post-fixed in 4% PFA at 4 C overnight and cryoprotected in 30% sucrose for 23 days

The drug development partners had been seeking approval for patritumab deruxtecan, an antibody-drug conjugate (ADC), to treat patients with advanced or metastatic NSCLC bearing certain genetic mutations