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Besides the effects of the local extracellular signals, multiple factors in neuronal migration, fate determination, and morphological maturation depend on intrinsic transcriptional networks, as shown by various fate mapping and clonal analysis studies (Florio and Huttner, 2014)

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Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML

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This highlights the possibility that LST-1 and SYGL-1 may regulate the proliferation vs differentiation balance independently of each other, and potentially through distinct mechanisms