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Therefore, GLP-1RAs hold promise as a novel therapeutic approach for diabetic patients with reduced -cell mass, stimulating -cell proliferation and differentiation ( FIGURE 3 4.4 Inhibition of -cell apoptosis Apoptosis plays an important role in the pathophysiology of diabetes
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In an in vitro model, incubation with DHEA alone decreased cell viability of neurons, while incubation with DHEAS alone had no effect [103]
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