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Dosing Recommendations Based on phase 2 trials, the following dosing strategy has been employed: Starting dose: Typically 0.5 mg once weekly, with gradual increases Titration phase: Progressive increases to 1 mg, 2 mg, 4 mg, and potentially up to the maximum dose of 12 mg weekly Maintenance dose: Once the target or maximum tolerated dose is reached, patients continue at that level for ongoing treatment[8] Titration Strategy The gradual dose escalation approach serves several purposes: Minimizes gastrointestinal side effects through gradual adaptation Allows for monitoring of tolerability at each dose level Provides flexibility to pause or slow titration if side effects emerge Different starting doses (2 mg vs 4 mg) were tested, with lower starting doses showing better tolerability[4][8] Following the recommended titration schedule is crucial for maximizing patient adherence and treatment success

This consensus paper aims to provide guidance on the utilization of DPP-4 inhibitors in T2DM management from an Indian perspective

This article summarizes GPCR targets and pipelines highlighted by AstraZeneca, Pfizer, and Eli Lilly at JP Morgan Healthcare Conference 2024.

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Grce une biodisponibilit amliore et une absorption plus efficace de la substance active (smaglutide) travers la paroi de l'estomac, le comprim de 1,5 mg offre exactement la mme efficacit thrapeutique et rgulation de la glycmie que l'ancienne variante de 3 mg, mais avec une quantit absolue plus faible de substance active par comprim