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Starting doses of basal insulin (NPH or analogue) are estimated based on body weight (0.10.2 U/kg per day) and the degree of hyperglycaemia, with individualised titration as needed

Effects of GLP-1RAs on ad Libitum Food Intake Based on the initial observation that low-dose intracisternal administration of GLP-1 reduces food intake acutely in rodents (52, 53), and similar findings of exogenous IV administration of GLP-1 in healthy humans (54), GLP-1RAs have been found to reduce body weight substantially in both T2D and obesity

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Exploring Other Factors Some people find that dose, timing, or food patterns influence their response