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2026 Jan-.

Given the lack of individual preclinical models of PCOS that recapitulate all the metabolic, endocrine, and gonadal traits of the clinical syndrome, pharmacological testing was conducted in parallel in these two PCOS models, which are among the most reliable to mimic the metabolic and gonadal phenotype of women with PCOS 36,37 , capturing also the heterogeneity of this condition 38

However, a randomized placebo-controlled trial evaluating liraglutide in glucose-tolerant obese psoriasis patients showed no significant changes in PASI or Dermatology Life Quality Index (DLQI) scores after 8 weeks of treatment compared with placebo treatment [209]

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dose reduction or medication discontinuation may be necessary to prevent complications