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However, native GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4) and cleared renally, giving it a plasma half-life of only 12 minutes far too short for practical research or clinical application
231 Ikeda, F
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in Diabetes, Obesity and Metabolism (2022), tracked participants after they stopped semaglutide following 68 weeks of treatment
Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus: a randomised controlled trial (LEAD-5 met+SU)
