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At therapeutic doses, GLP-1 drugs cross the blood-brain barrier and dampen dopamine signaling in the brain's core reward center, making addictive substances less rewarding

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Weeks 3 to 8: Building Metabolic Momentum The 3- to 8-week window is when most patients begin noticing weight reduction on the scale, usually 2 to 5 pounds per week depending on baseline body composition and adherence