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Likely, the challenges inherent in quenching thiol/disulfide exchange reactions, and the possible contamination of samples with the contents of cellular compartments with widely differing redox potentials, contribute to this discrepancy [91]

To keep the internal medium in a reduced state, biological evolution created a complex redox buffering system

Due to the high proportion of lipids, the central nervous system is most vulnerable to free radical damage [3, 23]

Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Abeta42-induced Alzheimers disease-like symptoms

Similarly, fisetin, a flavonoid found in strawberries and other fruits, activates SIRT1 by increasing NAD + levels while also reducing oxidative stress and inflammation 179 (Fig