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For example, abnormal iron levels are observed in semen specimens of smoking patients with asthenospermia, suggesting a role for ferroptosis in male reproductive dysfunction

DFO was shown to scavenge various radicals, including superoxide, hydroxyl radical, and HOCl

Alcohol consumption: Regular or heavy drinking depletes glutathione and increases oxidative stress, counteracting supplementation benefits

Beyond presynaptic deficits, chronic dopamine depletion leads to postsynaptic adaptations, including downregulation of D2/3 receptors and inflammationmediated desensitization of downstream signaling pathways [201]