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Description
Clearance can be estimated directly from the plasmatime concentration curve by: where D o is the dose and Since In summary, clearances may be expressed mathematically as: 5.13

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The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease

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Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov, AV, Greenamyre, JT
