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Safe Use, Mitigation Strategies, and When to Consult Your Provider To minimize glutathione depletion risk: stay within recommended dosing limits (maximum 3,0004,000 mg/day for adults), avoid chronic daily use without medical guidance, maintain adequate nutrition (protein, vitamins B6 and C support glutathione synthesis), and consider alternatives like physical therapy or NSAIDs where appropriate

There is also a risk that, because it promotes blood vessel generation, it might also speed the growth of tumors, if the user happens to already have one

Since exercise training can modify the number and cargo of extracellular vesicles which could partly mediate exercises benefits for the cardiovascular health, extracellular vesicle-based therapies prompt further investigation