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Orlistat, phentermine/topiramate, naltrexone/bupropion, and the incretin-based drugs liraglutide and semaglutide, both GLP-1 receptor agonists (GLP-1RA), and tirzepatide, a biased dual GIP/GLP-1 receptor agonist, are currently both FDA and EMA approved for the management of non-syndromic obesity 10

ARA-290 (cibinetide) is currently investigational and not approved by the FDA for routine therapeutic use

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For instance, BPC-157 - a synthetic peptide - has shown promise in animal studies for enhancing collagen organization, blood vessel growth, and dampening inflammatory pathways to improve overall musculoskeletal healing

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