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This response helped in detoxifying ROS and maintaining redox balance, contributing to cold stress tolerance

10.1371/journal.pone.0026915 6

Physiological and pathophysiological roles of metabolic pathways for NET formation and other neutrophil functions

This process ultimately results in damage to the cell membrane and cell death ( In ferroptosis, GPX4 is a critical inhibitor that prevents lipid peroxidation accumulation by reducing lipid peroxides

We did not observe any acute or chronic pathologies in other organs, including the heart (cardiomyocytes, interstitium, and vasculature) and the kidney (glomeruli, tubules, interstitium, and vasculature) (Supplementary Fig
