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652,653 Although the primary TBI caused directly by external forces is irreversible, the secondary TBI can be alleviated
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Indoleamine 2,3-dioxygenase 1 (IDO1) is a key enzyme in the catabolism of tryptophan (Trp) via the kynurenine (Kyn) pathway and plays a critical role in inducing immune tolerance, making it an important immune checkpoint
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