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doi: 10.3390/ijms241310998 10 GewertB.MacLeodM.BreitholtzM

This response is often coupled with the selective activation of ATF-4 translation, which mediates a protective response including the upregulation of expression of amino acid transporters and de novo synthesis pathways 35,49

Through its interactions with sulfur and nitrogen metabolism, with ROS and ascorbate via peroxidases and DHAR, with NADPH via GR, with protein thiol-disulfide groups through GRX, and with signaling metabolites and hormones via GSTs, glutathione is an outstanding candidate as a central hub molecule whose status can modulate other signaling pathways

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