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MS under review) revealed that autophagosomes and multivesicular bodies (MVB)/late endosomes, selectively sequester smaller-sized LDs, while larger LDs more frequently interact with the cytosolic adipocyte triglyceride lipase, (ATGL) the rate-limiting enzyme in triglyceride lipolysis

This can be achieved through various methods such as sonication, freeze-thaw cycles, enzymatic digestion (e.g., lysozyme treatment), or mechanical disruption (e.g., French press)

Host selenoproteins may be targeted at the protein level by the SARS-CoV-2 main protease (Mpro) Another mechanism by which SARS-CoV-2 could interfere with host selenoprotein function is by targeting it at a post-translational stage, via proteolytic degradation

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The resulting square-planar coordination geometry produces a stable copper-peptide complex with characteristic spectroscopic properties