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This might be targeting angiogenesis and NOs cytotoxic and damaging actions but maintaining, promoting, or recovering their essential protective functions [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40]

Saito and colleagues recently described elevation of casp-1 expression levels alongside NLRP3 in the cerebellum of mice fed cuprizone for 6 weeks [333]

doi: 10.1126/scitranslmed.aaa3863

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While this idea is somewhat simplified, its intriguing His hypothesis suggests that the sudden influx of B12 can kickstart repair processes, and if there has been long-standing damage, the rapid onset of these processes might overwhelm the system, causing a temporary worsening of symptoms