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In addition, analysis of the synergistic effects of alcohol, obesity and smoking has shown that patients with this combination have a 7.4 times higher risk of developing HCC than do patients with only one of these risck factors (OR: 7.4, 95%: CI 2.1 to 14.6)

3ad), implying that CCl 4 -induced p53-dependent cell premature senescence were improved by IGF-1 gene therapy

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