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Moreover, increased expression of TET enzymes, coupled with decreased DNA methyltransferase (DNMT) activity, has been shown to result in the hypomethylation of other immune-related genes such as CTLA-4, further enhancing the suppressive function of Tregs in the tumor microenvironment and promoting tumor progression (Sasidharan Nair et al., 2018
Table 1 Demographics of the participants in the four treatment groups
A., Reznik, E., Lee, C.-H., Creighton, C
