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Therefore, we hypothesize that LA can reactivate Nrf2 by dissociating it from Keap1 and phosphorylating Nrf2 itself, although the mechanisms need further investigation

10.1007/PL00006984 J

ATP citrate lyase inhibition can suppress tumor cell growth

found that signal transducers and activators of transcription 3 (STAT3) promote MYC expression in tumor cells in AML, which in turn regulates the transcription of amino acid transporter SLC1A5, promotes Gln metabolism in AML cells, and oxidative phosphorylation (OXPHOS) of leukemia stem cells (LSCs)

For instance, analyzing the most recent TCGA multidimensional omics data revealed that multiple iron-related genes ( e.g., scavenger receptor class A member 5 (SCARA5), erythroferrone (ERFE), lipocalin 2, transferrin receptor 2 (TFR2), solute carrier family 11 member 1 (SLC11A1), and cytochrome B reductase 1 (CYBRD1)) were dysregulated in different cancers, and this outcomes may be associated with aberrant DNA methylation[112]