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additionally NAD + can be generated in the mitochondria from NMNAT3 80 , whose activity has been shown to be required in cells 77 , but dispensable in vivo as NAD + can be replenished through other pathways such as import from the cytosol 81

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Clinicians use them for pernicious anemia, postbariatric surgery, and other causes of malabsorption, and sometimes to jump-start treatment before switching to tablets