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In cardiac surgery, randomized trials have reported inconsistent findings: one placebo-controlled study in 102 patients with chronic kidney disease, using postoperative serum creatinine change as the primary endpoint, found no renoprotective effect (267), whereas another trial in 70 patients undergoing coronary artery bypass grafting reported a reduction in AKI incidence with high-dose intravenous administration (268)
Combining such therapies may synergize these protective properties whilst excluding the toxic peripheral side effects, due to renal COX2 activation, observed with long-term lithium treatment
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Protein purification involves isolating proteins from the source, based on differences in their physical properties
