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Upon re-exposure to the food allergen, the allergen binds to IgE antibodies on the surface of the effector cells, resulting in the release of histamine, tryptase, platelet-activating factor, prostaglandins, and leukotrienes into circulation ( Figure 1-1 )

In addition to immune cells, other cell types such as airway epithelial cells may also contribute to trained immunity in allergic disease

This can be distinguished from the signaling effects of ketone bodies that would take longer, on the order of weeks

There are hundreds of varieties available on the market, either by themselves or in conjunction with other foods or confections, and chocolate and cocoa goods are only loosely categorized

J Intern Med 236 : 603617