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Figure 3 3.5 Control analyses for age or TSH level as confounding factors In addition to the above planned statistical tests, we conducted two post hoc partial correlation analyses to examine possible confounding effects of age or TSH level as confounding factors

A recent study in mature rat hippocampal neurons showed that l-carnitine and ALC protected the mitochondrial membrane potential and countered the decline in oxygen consumption rates and the rise in mitochondrial fragmentation provoked by A1-42 [81]

For example, a deficiency in manganese superoxide dismutase (MnSOD), a key mitochondrial antioxidant enzyme, has been shown to amplify mitochondrial oxidative stress

[52] A 2013 meta-analysis of 20 different studies concluded that thiamine supplementation can also improve cardiac function in patients with heart failure, [53] which is a great illustration of how energy insufficiency at the cellular level (in the form of ATP deficiency) produces disease in myriad forms

doi: 10.1016/j.jpeds.2011.08.004 59
