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These RONS can oxidize the cysteine residues on the peptidase domain of ACE2 receptors and RBD of SARS-CoV and SARS-CoV-2 S proteins, keeping them in oxidized (disulfide) forms, as opposed to reduced (thiol) forms [59]

J Biol Chem 273:1240212406 [DOI] [PubMed] [Google Scholar] Premont RT, Gainetdinov RR

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[DOI] [PubMed] [Google Scholar] 40.Sancheti H., Akopian G., Yin F., Brinton R.D., Walsh J.P., Cadenas E

It is a relatively unstable and highly reactive molecule that plays a dual role in biological systems, acting as both a signaling molecule and a source of oxidative stress in moderate levels (Kzlta et al